Epithelioid angiosarcoma of the bone with eosinophilia: report of a case and review of literatures
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چکیده
We presented a case of 46-year-old man who developed right foot pain and activity limitation 7 months prior to initial evaluation at our hospital. Radiographic evaluation demonstrated osteolytic lesion in the bones of toes and biopsy revealed the diagnosis of angiolymphoid hyperplasia with eosinophilia. Surprisingly, malignant angiosarcoma was diagnosed in resected specimen. Histologically, the whole lesion was composed with inflammatory infiltration and hyperplasia of vascular endothelial cells. Numerous eosinophils infiltrated in the stroma with the local formation of eosinophilic abscess. In superficial area of the foci, some endothelial cells were epithelioid like gravestones. However, irregularly anastomotic vessels, which were lined with nests or sheets of atypia endothelial cells, were the predominant lesions in deep area, and these cells showed eosinophilic or basophilia cytoplasm containing lumina, round or oval vesicular nuclei, large and red nucleoli. Immunohistochemistry study presented intensely positive expression of CD31 and vimentin, negative expression of CD68, CD1a, S-100, CK pan, SMA, CD34, EMA and FVIIIRA which suggested that the diagnosis of bone epithelioid angiosarcoma with eosinophilia. To our knowledge, it is an extremely rare case.
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تاریخ انتشار 2017